• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A nutritional supplement for the prevention and treatment of excessive intestinal permeability is provided. The treatment includes a dietary regimen of nutritional buffers, amino acid chelates, minerals and vitamins. Other components may include antioxidants, free radical scavengers, beneficial organisms, and intestinal tract-soothing herbs.
    公开号:CA2361323A1
    申请号:C002361323
    申请日:2001-11-07
    公开日:2002-05-07
    发明作者:Linsey Mclean
    申请人:Linsey Mclean；
    IPC主号:A61K33-10
    专利说明:
    NuTRITtaNA~. sUPPL~Mt;NT Ft~R THE PR~vPNTtoN ANA TR ATME T n EXCESS V TES IN 1. P M A 1 Y CROSS- FE C TO ELA D A PL CAT ON This application is a eontinuation~in_part of U.S. Serial No.09!431,724, filed November 2, 1999, which is a continuation of U.S.08/887,909, filed July 3, 1987, now U.8. patent Na. 5,976,579. BACKGRCtJND OF THE INVhNTION, 1. field of the nv~ntion The present invention relates to a nutritional supplement far treating and preventing excessive intestinal permeability in living systems. The composition of the present invention provides nutritional buffers to the gastrointestinal tract as well as buffered, optimal amounts of amcno acid chelates, minerals, and vitamins. Furthermore, the composition optionally may include antioxidants, free radical scavengers, beneficial organisms to restore intestinal health, and tract-soothing herbs. The composition may be adjusted far use by humans or by animals. II. QescLj~ption oythe Relevant Art in the past thirty years, there have bean many environmental changes affecting agriculture and the foods eaten by bath animals and humans. The mast notorious ttlree factors affecting nutritional status of our foods and feeds are toxic environmental chemicals, acid rain, and the commonly unrecognized impact of the new super phosphate fertilizers having the composition 0-0.-46. Toxic environmental chemicals fall into two general categories. The first category comprises organic compounds including pesticides, herbicides, solvents and other industrial chemicals. These organic compounds are known to affect hormone status !n aiological systems, mimicking both androgens and estragens. Healthy biochemistry includes the suppression af, activation af, and competition with natural hormones in the biological system, whether the system is plant, animal or bacterial in nature. The second category of toxic environmental chemicals comprise heavy metal atjd halogen compounds. Heavy metals are known to substitute them&elves for nutritional metals or minerals in enzyme systems and outer biochemical pathways that are dependent upon nutritional metals or minerals. This especially occurs under conditions of excessive exposure to the heavy metals combined with nutrient metal or mineral defciency. Halogen compounds (containing fluorine, chlorine, bromine, andlor iodine) are often organic as well, multiplying their potential for toxicity. The law df halogen replacement, which describes the chemical personalities of the halogens, states that the electro-negativity of the halogens decreases progressively with increase in atomic number.each halogen tends tp displar"e those below it in the Periodic Table.Fluorine is the most electronegative of all of the halogen elements, followed by chlorine, bromine and finally iodine. Iodine is necessary for the thyroid hormone thyroxine which plugs into special receptor sites on the cell memf3ranes of every cell in an animal system, regulating the speed of biochemical reactions at the cellular level. Thus, thyroxine is the master regulator of basal metabolism. The molecule thyroxine is c~amposed of two molecules of the amino acid tyrosine bonded to four molecules of iodine, commonly called T4. The T4 molecule, known as the storage form of the thyroid hormone, is then enzymatically deiodinatad to T3 (whereupon it contains only three iodine molecules) to free a bonding site for the receptor on the cell membrane. This now becomes the active form of the thyroid hormone in the anima! body.because the law of halogen replacement, iodine, which is essential in animal and human biochemistry, brings up the rear in halogen chemical activity. iodine is the (.east active of this family and can be easily displaced and substituted for py any of the other halogens. Wixh reference to the thyroxine molecule, many intermediary biochemical pathways can be shut down in thyroid metabolism, as enzymes, cofactors and feedback mechanisms become confused by the deception if such a substitution occurs. Medical testing and diagnosis of thyroid function and dysfunction are also confused by the similarity of electron clouds, and differences in size and molecular weight of the displaced substituted fighter halogens for iodine. False negatives and positives in medical testing are possible, as well as skewed autoantibody titres, from autoirnrnune responses directed at the improper molecule trying to mimic the natural one. The measurement of levels of T3 and T4, which is the typical thyroid profile used as a screening tool tar hypothyroidism in every medical office, can also be affected. Stat;stically, a full 60-65% of testees falling into the so-called "normal" category are symptomatic far clinical hypothyroidism andlor myxedema assoGia~ted with hypothyroidism. The potential for biochemical disaster involving this displacement substitution, coNpled with the higher toxicity of the other halogens themselves, sets the stage for the epidemic syndromes seen today which era variously depicted as chronic fatigue syndrome, clinical depression, morbid obesity, attention -__ _ -_ _. _. - _ _ .- _ - ~ ._ ___~ 02361323 2001-11-07 deficit disorder (ADD), attention deficit hyperactivity disorder (ADHa), and addiction syndromes resulting from c4inica) depression. These syndromes are frequently characterized by many faulty blood sugar regulation and hormone imbalances which are conditions involving lowered basal metabolism and metabolic rates. These statistical observations are exemplified in universally lower basal temperatures, particularly noted in the human population. Hardiy anyone regularly records a basal temperature of 98.6° F anymore- New "narmals", reflecting these statistical observations are not associated with optimum Zp health, and are more in the 96-97° range. This halogen causative factor in particular is highlighted in this invention, because thyroxine function in the body is Known to regulate the absorption and metabolism of calcium and magnesium, the biological system's major catian buffers. Acia rain affects the Ph of the sail and subsequently the plants Z6 grown on it, showing a drop toward more acidic levels. Acid rain is known to affect both macro and micro mineral status as bioavailability for plants in a negative way, by binding and making these essential elements unavailable for use. Plants have not responded to the new sail nutritional deficiencies because they are simple organisms, much less complicated than the animal organisms who rely on them for food.plant essential nutrients are limited to nitrogen, phosphorus, and potassium, while the animals (including man) who depend an them for food require many additional elements such as copper, zinc, manganese, cobalt, selenium, vanadium, etc. Plants simply take these additional elements up only incidenfahy. These additional elements do not significantly increase crop yield, for, as previously mentioned, they are not absolutely essential to plant growth. Upon recognition of these deficiencies coming through our foods and feeds by the more - ~ ' -' --- - ~ CA 02361323 2001-11-07 FJnutritionally aware Arganic farming movement, a great effort was launched some 2Q years ago to improve the elemental nutritional status of sails, and hopefully the resulting foods and feeds produced. This gr~at effort proved to 17e a failure, in that the fertilization practices involving the additional trace minerals previously mentioned did not -significantly increase crop yield, and, subsequently, did not offer a payback to the organic farmers who spent great quantities of money in this experiment. In fight of this information it now becomes more important to supplement these vanishing elements in the food of the '10 animals and man who depend upon these now increasingly mace deficient foods for sustenance and health. Super phosphate fertilizer, a relatively new invention of the fertilizer industry, was created in response to the oil embargo of the early 1970s which so crippled the American economy. Traditionally, farmers used 30--4o t)as. per acre of conventional phosphate fertilizer for optimum grain production. In answer to the great demands of agriculture during this embargo for ail-based phosphate fertilizers, much research was done to try to reduce our requirements for oil in this industry thus to reduce the kind of dependence on foreign oil we had 2Q developed. The fertilizer industry was one of the largest users of oil resources. With super phosphate fertiliser, the ~0-~0 Ib. requirement per acre of traditional phosphate fertilizer can be reduced to 2 lbs. per acre, which is a highly significant savings. The reduction can be accomplished because of the increased biological activity of the new phosphate chemical forms over the old phosphates. This higher phosphorus activity places a greater pressure against calcium ahd magnesium activity, the phosphorus element's antagonists and natural balancing elements. Calcium and magnesium are also the living organisms' major buffering elements, involved both at the cellular level as welt as in the digestive tract. Greater phosphate activity, relative to calcium and magnesium activity, translates to the farmer as accelerated maturation of the grain plant, earlier harvest times, and less plant residue on fields after harvest due to stunted plant green growth dependent on calcium and magnesium. These super phosphate residues are now coming through food and feed sources for our food animals and ourselves. It is no coincidence that human population statistics are now showing earlier menarche and earlier menopause in girls and women. Population statistics also confrrn higher Calcium and magnesium deficiency syndromes, such as osteoporosis, at an ever earlier age as wEll. This reduction of calcium and magnesium bioavailability and biological activity as a result of tile combined negative environmental ~5 and technological infiluences causes depr~ssions in buffering activity at the calf level In the animal system, allowing the accumulation of higher levels of acidic nypraducts of cell metabolism, such as lactic acid. In the digestive tract, this downward Ph shift contributes to the formation of ulcers and malabsorption syndrome, from incompletety buffered and ~p therefore unabsorbable nutritional digestive components. The downward Ph shift in the digestive tract also shifts the microbiological environment toward a favorability of acid accommodating, acidophilic and fermentatwe organisms, instead of those most suitaple to aid digestion. The desirable symbiotic organisms are responsible for the production of ~-complex vitamins, certain essential amino acids, and other intermediary metabolites that aid the host bfldy. The host body has evolved to rely on this source of essential nutrition. Loss of this essential source of nutrition presents Significant nutritional deficiencies affecting the inherent quality of fife.The combined effect of the downward Ph shift in the digestive tract, associated with various environmental changes described above, is the factor acting as the major contributor to excessive intsstittal permeability described as "leaky gut syr~droms'', with the corresponding associated allergy, parasitic and immune depression syndromes well documented in human medicine.excessive intestinal permeability (ar "leaky gut syndrome") is the 1 Q inability of the biological system to properly buffer the thyme ingredients of the small intestine. The lowered Ph then irritates the membranes of the digestive system causing fragility and breakage of cell membranes at the cellular Igvet, and leakage of digestive contents outside the digestive tract. Gell membranes are only two molecules in thickness, composed of a high percentage of protein, whose peptide bands linking the amino acids, are highly susceptible to subtle downward Ph shifts.'these lowered pHs cause proteins to deform and change shape. This deformation can be demonstrated by adding milk to orange juice and watching the curds of deformed milK proteins form, in response to the lowered Ph of the mixture containing citric acid. if the curdled milklarange juice mixture is then buffered with baking Soda, or the like, raising the hh, the curdles disappear and the mixture creams, as the milk proteins regain their shape again. When the proteins of the cell membranes became deformed from overexposure to this lowered Ph shift action, the micropores in the ceh membranes, which allow for influx of nutrients arid outward flow of cellular waste products, become deformed as well, and essentially close off- This triggers inflammatory response and cell death by starvation and waste intoxication. The integrity of the cell mem! cane is else essential far the electrical and energy mechanisms of the cell, with the catian electrolytes, magnesium and potassium inside the cell, balancing the canon electrolytes, calcium and sodium in the fluid outside of the cell. This function is similar to a car battery with its two chemical cells divided by a metal plate. t=tectrical activity across this plate is the source of elactricahchemical energy in the battery. The cell membrane is akin to this media! plate, across which alectricallchemical activity t~tween the cations takes place. This is a major source of energy for the cell. pestruction of the cel! membrane, alt ar in part, allows calcium and radium to rush into the interior of the cell, essentially shutting down this electricahchemical activity. The same thing happens to a car battery when the plate between the two cells is removed and chemicals from both cells are allowed to combine. When the cell membrane is destroyed, the cell itself is effectively destroyed. if this happens to take place along the intestinal walls of the gastro-intestinal tract, commonly the first area of the body affected by excess environmental acidity, fracturing of tile tissues of the intestinal waifs occurs. This then opens the Boar. sa to speak, far invasion of inner tissues and cavities of the 2A body by digestive contents. Here is where the allergic reactions and migrations of oppprtunistic micrabiolagical andlor parasitic organisms are born, overwhelming the immune system to virtual exhaustion. Combined with the previously-described induced nutritional deficiencies, immune depression commonly results. Carrier proteins of trace minerals from the digestive tract era also affected, contributing to nutritional mineral deficiencies. Since virtually any protein can be affected anywhere in the body by these lowered Ph changes, the biochemical activity of enzymes, y~~ CA 02361323 2001-11-07 hormones, biochemical receptor sites, feedback mechanisms, and neurotransmitters are also affected, since these are proteins. This carnpliGates physical conditioning and performance, as well as promoting behavioral changes, inGuding clinical depression, anxiety, learning disabilities, add hyperactivity syndrome, among others. In fact, the combined affects of all of these aforementioned causative factots are the root of the commonly diagnosed gigantic category of "environmental ilin~ss~. St~l]WMARY OF ALE ~.i=sEN~~yvE~on~ The present invention provides a sof~ttion to the problems described above toy offering a nutritional supplement for treating and preventing excessive intestinal permeability in living systems. The composition of the present invention provides nutr'ttional buffers to the gastrointestinal tract as well as buffered, optima! amounts of amino acid chelatss, minerals, and vitamins_ Furthermore, the compositlan optionally provides antioxidants, free radical scavengers, beneficial organisms to restore intestine! health, and tract-soothing herbs. DETAILED f !=scRIPTION a~ THE PREFERRED EMBODI,~Et~,T~ of Tla~ PR~si~rv~~ INVENyON The present invention mitigates the adverse biochemical and behavioral responses to the described environmental causative factors, in these general ways:'t. To supply nutritional buffers to the gastrointestinal tract, to aid the animal body restoring the proper buffering of thyme, which in turn promotes proper absorption of nutrients, and protection from excess acid destruction of cell membranes in the digestive tract, thereby preventing excessive intestinal permeability. These nutritional buffers also aid in the promotion of health and in the heating of existing gut fractures. The maintenance of proper intestinal Ph is also important in maintaining resistance to opportunistic migrations of micropiolt~gical andlor parasitic organisms. These pathogens and potential pathogens are normally ingested in encapsulated cyst fiarm, and must fee exposed to a lengthy time in acid media to break the encapsulation and become free laving as a trophozoite form. This active, free living form is capable of camplstirlg its life cycle and reproduction_ Cystic encapsulation in the Inactive Sieges of the fife cycles of these microbiological andlor parasitic organisms provides protection from environments nrat conducive to the completion of their life cycles. This adaptatipn assures protection from extinction and continuation of the species, since these organisms have no control over the environments in which they find themselves. A perfect and representative example is seen today as the epidemic of a disease not previously observed in the horse population of the United States to any degree. Galled "irquine Protozoal Myeiitis", this disease ~s descriptive of protozoa! trophazoites ar free living forms, migrating through the tissues of the taody, including the central nervous 2a system, and causing various and sundry larnenesses, ataxias and behavioral changes. At this time no single causative agent has been identified, taut many different protozoa have been implicated. What makes this example so relevant is the fact that the horse, a grazing vegetarian, has become susceptible to such a huge degree as to cause up to 80% of the horse population of a given area to test positive for blood arttiaadiss to the most commonly implicated, and the mast notoriously invasive, of the protozoa species, Sarcacystis neurone. This pathogenic protozoa has previously only bean found in carnivores, such as opossums and raccoons. It is known that carnivores have a lower gut Ph than vegetarians, and particularly vegetarian grazing animals such as horses. 1 he environmental changes that have been descriraed here explain why the previously unthinka!'le is now commonly observed whereby that grazing vegetarians (in this example, horses) would now --w become susceptible, en masse, to the same diseases and parasitic infections that plague a carnivore. Statistics from university research over ten years ago descrit~e the incidence of ulcers in horses occurring in petween 52 and 9Q°!a of the entire parse population, relating to 14 different breeds, ages and work Toads. gioto~;calfy, this should not be possible unless the living environment of alt of these horses has changed dramatically in the same ways and far every horse to significantly lower the Ph of the digestive tracts of these grazing vegetarians. Ulcers in grazing vegetarians should not even be possible under normal conditions, indicating that the abnormal exists. Microbiofogical andlor parasitic organisms have evolved a mechanism by which they can monitor their environments and respond only when conditions are favorable for completion of their life cycles. This adaptive advantage is the development of a thick wall around a "hibernating", inactive stage of life. Only after lengthy exposure to a low Ph liquid environment, which in effect "digests" or destroys this thick wail and triggers activation of the organism, does the organism emerge as a free form or trophozoite, able to complete its life cycle and reproduce. One can see how a protective mechanism, such as this thick wall, can prevent extinction for the species and promote proliferation. If the encapsulated cyst happens to land in a mud puddle caused try rain, only to dry up within a short time, the conditions would not have peen met to satisfy the requirements for life cycle completion. CA 02361323 2001-11-07 ' If the encapsulated cyst were to fall, on the other hand, in the waters of a swamp, the Ph of the wafer, sufficiently law from the rotting vegetation in the water, would trigger the destruction of the thicK wall and activate the organism to complete its life cycle. In this way the organism would, by the Ph of the water, "know" when conditions were right which is in turn dictated by the length of time the water had been standing. Longer standing water is generally lower in Ph, and the chances are that the longer the water has been standing, the longer it will continue to stand to provide adequate time far completion of one or many life cyGes.1Q Exposure to excessive acids in a digestive tract, not able to be bufifered property within a suitable time frame, mimics this natural chain of events in the wild for these microorganisms. Hence, their opportunistic, pathogenic nature and their epidemic disease occurrences in previously non-target hosts. The active trophozoite farm, or free flying forms of these organisms, released from their protective encapsulation by excess gastrointestinal acids, are now capable of migration through tissues, even to cerebrospinal fluid, causing ataxias and other various and sundry physical dysfunctions, depending upon the location of migration 2Q and the corresponding inflammatory reactions they elicit. Species not cammaniy regarded as "pathogenic" or having the innate ability to invade the body on their own, can, with the door to the interior tissues and body cavities opened through membrane fractures or increased intestinal permeability, now become opportunistic pathogens. This 2S situation is likened to an open door to a candy shop, with candy sitting out in fuh view of a 5-year old child passing by. Normally, this young child wouid not think of g4ing into a candy store through a closed door to help himself to the candy. Sut, the situation ctlanges as opportunities i and temptations arise with the open door. A young, innocent child becomes, under the right conditions, a thief. Sa too with common intestinal inhabitants previously r~arded as innocent or ~non-pathogenic and normal" fauna and flora.In the current epidemic Qf equine Protozoa( Myelitis, previously thought harmless, species of intestinal protozoa show up in increasing numbers as trophozoites or free living forms, in fresh fecal smears and fresh and hemolyzsd blood smears, corre$ponding to the severity and numbers of physical dy$functians.
    2. To supply in a buffered, bioavailable form, optimal ampunts of macro and micro nutrient metals, minerals, and vitamins necessary to promote optimum health, to overcame soil and food mineral and nutritional deficiencies, to fuel biochemical pathways and enzyme systems in the living animal system, and to restore proper immune function, so necessary to destroy invaders of tissues and body cavities that have already entered through the intestine! walls, via increased intestinal permeability or "leaky gut syndrpme".
    3. To provide ample amounts of antioxidants and free radical scavenasrs, which reduce inflammation and inflammatory responses, 2Q themselves contributing to physical andlar behavioral dysfunctions.
    4. To supply ~propiotic~ cultures of beneficial organisms to replenish intestine! microbes necessary for good intestinal health. Ta soothe the inflamed gastrointestinal tract and provide immediate comfort tc~ the affected body with soothing herbs such as peppermint. Preferred components of the composition of the present invention include the following. Calcium carbonate, an antacid, in the approximate amount of between about 20.0% and about 35.0% by weight. Sodium sesquicarbonate, used in bath crystals and as a food additive, in the approximate amount of between about 10.0% and about 18.0% by weight. Note that potassium elC~rr,n~~to "r ~.bicarbonate or any ether carbonate source could be substituted for sodium sesquicarbonate, if proper calculations for carbonate equivalent ions were done. Sodium bicarbonate is eat as free flowing far manufacturing purposes and contains, on the whale, more sodium per ~e carbonate or buffering per kilogram. This is less desirable in humans, but satisfactory for other vegetarian spscie$ lifce horses, who tend to retain potassium and require more svdrum. Magnesium oxide, used irr pharmaceuticals and cosmetics, in the approximate amount of between about 18.0% and about 28.0% by 15 weight. (Magnesium carbonate could be used in lieu of ar in addition to magnesium axrde, the weight percent of the magnesium carbonate being deterrnined given consideration of its lesser elemental percentage.) I7rmethyl glycine tiCL in the approximate amount of between 20 about 0.~°!o and about O.g% by weight.vitamin A (commercial supplEment) in the approximate amount of between about 0.01 % and about 0.05°/a by weight. A vitamin B~camplex blend, essential for the maintenance of neurolagic and cellular function, in the appraxirnate amount of between 25 about 0.5% and about 1.5% by weight. Vitamin C (preferably coated} in the approximate amount of between about 1.0% and about 5.0°/a by weight. l CA 02361323 2001-11-07 l ~t FJ Vitamin D (commercial supplement) in the approximate amount 4f between about 0.01 % and about 0.05% by weight. Vitamin ~ (50%) (tocopherai), essential in nutrition and used in medicir~as, as an antioxidant for fats, and as an animal feed additive, in the approximate amount of between about 0.5~° and about 2.5% by weight. Note that various percentages of vitamin E can be used as equivalents, with proper calculations to convert, a 50°/° vitamin f~supplement is most available to us at this time. A mixture of tappet, zinc, manganese and potassium amino acid chelates (a "SOp" mixture) in the approximate ampunt of petween about 2.0% and about 8.0% by weight. Zinc amino acid chelate in the approximate amount of between about ~ .0% and about 3.0~° by weight. Calcium amino acid chalets in the approximate amount of between about 5.0% and about 10.a% by weight. Magnesium amino acid chalets in the approximate amount of between about ~ 6.0% and about X8.0% by weight. Probiotics bacterial culture (for use as bacteria! intestinal inocuiant) in the amount of between 4.0% and about 9.0% by weight. In adaition, a favoring compound is provided in an amount of sufficient to enhance palatability in animal mixtures in the amount of between about 9.5°!° and about 3.5% by weight. While a variety of flavorings may be used, one preferred flavoring is peppermint oil. Note that other bioavailabie Chemical farms of minerals may be substituted for the mineral chelates if the equivalent numbers of elemental m~nerals are met. Daily dosage is calculated by weight and species. Typical dose for horses would be 75-250 grams per day of the formula, depending -- -- -- - - - - -- - - --- - - -- ~ CA 02361323 2001-11-07 ~' y l on ache, breed, body size, sex and workload or stress level and symptomology.(n addition, the weight p~rcent of the buffer may be lessened in the overall formula by between about 10°h and 40°/° by weight in potency for carnivores as opposed to vegetarian animals who are more accustomed to maintaining a higher Ph in their digestive tracts. Over-alkalixing a carnivore will make these animals ill as they are more attuned to higher aadity. Accordingly, the composition formulation may be attjusted sc~ as to be species Specific. Additional optional components might include thyroia supplement and anti-ulcer or other upper gastric medicaments_ The average daily dose for an adult person would be 7.5 - 30 grams per day, depending on body size, stress level and symptomology. Animals and humans showing signs of autoimmune ar chemical hypothyroidism or hypoadrenaiism would require the high end amounts. XA PL A typical batch ofi the formula consists of the following components, based upon weight (and percentage by weight) with all values being Za variable to +l- 20%: Calcium Carbonate . . . . . . . . . . . . . . 140 lbs., 0 oz. (23.1 °I°) Sodium Sesquicarbanate . . . . . . . . . . . 50 lbs., 4 oz. (11,5a/°) Magnesium Oxide . . . - . . . . _ . . . . . . 82 lbs., $ ozs. (19.1 %) Dimethyl Glycine HCL. . . . . . . . . . . . . ~ . 1 lb., 13 azs. (0.4°I°~ Vitamin A . . . . . . . . . . . . . . . . . . . . . 0 Ib., 3.5 ozs. (0.06°/°) Vitamin B-complex blend . . . . . . . . . . . . . 4 Ibs., 1 oz. (0.9°!0) Vitamin C (coated) . . . . _ . . . . . . . . . . . . 10 Ibs., 0 oz. (2.3°/0) - '-. -- - ~ CA 02361323 2001-11-07 ~ , Vitamin D . . . . . . . . , . . . . . . . . . . . . d Ib., 3.5 ozs. (f .06°/0) Vitamin ~ - [50%J pure . . . . . . . . . . . . . . 3 las., 2 ozs. (0.7%) SQD Mix (Cu, Zn, Mn, and K amino acid Ghelates) . . . . . . _ . . . . . . . 12 fbs., 8 ozs. (2_8%}g Zinc Amino Acid Ghelate . . . . . . . . . . 6 fbs., 9.5 ozs. (1.5%} Calcium Amino Acid Ghelate . . . . . . . . . 28 lbs.. 0 oz. (fi.5°/°) Magnesium Amino Acid Ghelats . . . . . . 02 fbs., 4 oz. (21.3%) k.i~e probiotics bacterial culture (intestinal innoculants) . . . . . . - - 22 lbs., 4 cras_ (5.2%) Peppermint oil (for flavoring) . . . . . . . . . 8 Ibs., 4 oxs. (1.9%) (the amount of flavoring may be adjusted for taste) pcssihfe Administrative Protocols As noted above, dally dosages are calculated by weight anti species. Average daily dose for an adult person would bet petwaen ~ 5 about 7.5 arid 30 grams per day, depending on body size, stress level and symptomology. With respect to animals, and taking horses for example, the typical dose for horses would be between about 75 and 250 grams per day of the formula, depending on age, breed, body size, sex and workload or stress level and symptomofogy. Also as noted above, animals and humans showing signs of autoimmune or chemical hypothyroidism ar hypoadrenalism would require the higher end amounts. The desired regime, whether for humans or animals, might also include administration of a specific thyroid protocol. Administration may be made as wel! according to a particular feed schedule or regimen. It also may as well include measures to regulate the user's body temperature through such measures as sauna or hot tub applications.in same cases, such measures as acupuncture or the application of external electromagnetic fields may be applied.lncaraa ation it tn t a User's Die if administered to humans, the composition of the present invention may be provided in liquid form as through a supplemental drink or may be in dry form as a powder or incorporated into a bar or otrier foodstuff. If administered to animals, the ,composition of the present invention may be provided by way of addition to the animal feed at the point of manufacture. The composition may alternatively tie administered to animals in the form of a food supplement. Cl~~c_al Trials Clinical trials were done an performance horses of the highest caliber, either racing horses or high level show horses, where trainers were sensitive enough to observe subtle changes in attitude, behavior --and physical performance. Horses were chosen for clinical trials because of the high level of focus on the epidemic proportions of ~au'sne Protozoal Myelitis, the development of two new diagnostic tests used in bath blood and cerebrospinal filuid (CSF) testing for antiboaiss to Sarcocystis and DNA for the presence of the actual organism. These p tests monitor the presence of the actual organism and its extent of migration through the body as well as the ability of the immure system to respond to it. There is as yet no such testing for humans, except for C-reactive protein which is not specific for general inflammatory responses. Horses also do not exhibit the placebo effect as they da not know what they are being fed or for what purpose. Furthermore, their perFormances are measurable in ll5th of a second increments. Their Toad sources are the same everyday, as well as are their living conditions. They are not subject to such human traumas as emotions, excessive living, relationship-induced depression, addictions to nicotine, alcohol or recreational drugs (al4 monitored by the racing commission and Federation 1~ausstre Internationals [!'Ei~). This maKes them the ideal candidates far clinical trials as they are conditioned athletes, receiving the highest level of care, with essentially na other outside factors to influence the data. Clinical trials were conducted using the following protocol:b ~ Videotaped complete neurological examination by a licensed veterinarian whose practice is limited to, and specializes in, performance horses ~ Feeding of tn~ formula three times per day incorporated into a total specialized diet ~ to ~ Repeated videotaping by the same veterinarian of complete neurological exam every two weeks to monitor progress ~ Evaluation of progress Two categories of horses were studied, both having peen positively diagnosed dy blood and CSF for EPM. A. Horses successfully treated by the common prescription drug combination currently in use, but relapsed when taken off the drugs anywhere from five days to two months, alt other factors remaining the same ~CA 02361323 2001-11-07 B. Horses never having been treated with the prescription drugs but receiving the formula of the present invention instead. All ether factors remained the same. Results: Positive responses were noted in both categories of horses about the third day. l3etween the fifth day and the tenth day, a worsening of symptoms andlor a rise in temperature to low grade fever was often noted, indicating the beginning of a healing crisis initiated lay the restoration of thN immune system and a greater response co f4rsign organisms already in occupation of the interior tissues of the body. This healing crisis lasted from one to seven days, after which significant progress was noted which continued until full recovery and alleviation of the symptoms petween two and eight weeks depending on the severity of symptoms and the length of duration of disease. Compared to conventional drug therapy, horses administered the 1 b formula of the present invention suffered no ill effects, depression of the immune system ident~ed by lowered white cell count, muscle wasting, or depression so commonly reported with conventional drug treatment, and their end level of health attained was higher and with more successful performance results than with conventional drug therapy.24 The monitoring of hemolyzed and fresh blood samples for free living protozoal forms, migrated from the intestine, showed the presence of .-._ CA 02361323 2001-11-07 ' living traphozoites in untreated and relapsed horses, dut not in horses fed the invention beginning between three and five days after commencemsnt of treatment to the contusion of the trial two to four months later. This shows the effectiveness of the invention in preventing migration of free living or traphozaits farms to the interior tissues of the body as exemplified by their presence in blood. As a result of the success at these trials, most all of the trainers elected to keep their horses on the invention indefinitely. Micrabiotogical inspection of the fresh feces in horses under current prescription drug therapy, past drug therapy with relapse (category A), and untreated horses of Category B, all showed excessive traphozoite numbers, capable of migration, relative to encapsulated, harmless, cystic forms. Within three days of administering the invention, the relative numbEr of trophozoite or free living forms to the encapsulated, harmless forms, jb was greatly reduced, in same horses approaching zero, showing the effectiveness of the invention, preventing activation of at feast three observed species of prowzaa. Horses utilizing the invention also showed less susceptibility to secondary infections, with which some were constantly plagued, and 0 greater resistance upon exposure to contagious diseases exhibited by ~CA 02361323 2001-11-07 other horses in the same barn, showing the effectiveness of the invention and restoring the capabilities of the immune system. Horses that had been hindered biochemically in their training and performance and only marginally helped by up to six months use of "-conventional drug therapy were able to go to subsequently higher levels df training and performance after only three weeks use of the invention, showing the effectiveness of the invention in fueling and refueling normal biochemical pathways toward the restoration of health.1n comparison with conventional drug therapy, horses being fed 1p conventional drugs far between six months and up to two years still showed the same high numbers of free living or trvphazoite forms of protozoa as untreated animals in fresh fecal smears, and had free living forms present in hemolyzed and fresh blood as well. In fact, the lonser the duration c~f drug therapy, the higher the numbers of protozoa observed in the blood, indicating the probability of development of resistance to the drugs. The invention being thus described. it wit! be obvious that the same may be varied in many ways. Such variations are not to be ..regarded as a departure from the spirit and scope of the invention, and ;al! such modiftcations are intended to be included within the scope of the following claims.
    权利要求:
    Claims (21)
    [1] 1. A dietary supplement for the prevention and treatment of excessive intestinal permeability, the supplement including a carbonate and an oxide.
    [2] 2. The dietary supplement of Claim 1, wherein said chelate is an amino acid chelate.
    [3] 3. The dietary supplement of Claim 2, wherein said amino acid chelate is selected from the group consisting of copper amino acid chelates, zinc amino acid chelates, manganese amino acid chelates, calcium amino acid chelates and magnesium amino acid chelates.
    [4] 4. The dietary supplement of Claim 1, wherein said carbonate is selected from the group consisting of calcium carbonate, sodium bicarbonate, sodium sesquicarbonate, and magnesium carbonate.
    [5] 5. The dietary supplement of Claim 1, wherein said carbonate includes two different carbonates.
    [6] 6. The dietary supplement of Claim 5, wherein said two different carbonates include calcium carbonate, sodium sesquicarbonate, and magnesium carbonate.
    [7] 7. The dietary supplement of Claim 1, further including at least one mineral.
    [8] 8. The dietary supplement of Claim 1, further including at least one vitamin.
    [9] 9. The dietary supplement of Claim 8, wherein said at least one vitamin is selected from the group consisting of vitamins A, B. C, D and E.
    [10] 10. A dietary supplement for the prevention and treatment of excessive intestinal permeability and the neutralization of excessive acidity caused by environmental toxins, the supplement including selected amounts of a first carbonate component and a second carbonate component, said first and second carbonate components being different from one another.
    [11] 11. The dietary supplement of Claim 10, wherein said second carbonate component is selected from the group consisting of sodium sesquicarbonate and the ionic equivalent of sodium sesquicarbonate.
    [12] 12. The dietary supplement of Claim 10, further including a selected amount of dimethyl glycine HCL.
    [13] 13. The dietary supplement of Claim 10, further including one or more vitamins selected from the group consisting of vitamins A, B-complex, C, D, and E.
    [14] 14. The dietary supplement of Claim 10, further including one or more amino acid chelates selected from the group consisting of copper amino acid chelates, zinc amino acid chelates, manganese amino acid chelates, calcium amino acid chelates, and magnesium amino acid chelates.
    [15] 15. The dietary supplement of Claim 10, wherein said first carbonate component is provided in an amount of between about 20.0%and apout 35.0% by weight, said second carbonate component is provided in an amount of between about 10.0% and about 20.0% by weight, and further including an oxide in an amount of between about 18.0% and about 28.0% by weight.
    [16] 16. A dietary supplement for the prevention and treatment of excessive intestinal permeability, the supplement including a selected amount of a first carbonate component, a selected amount of a second carbonate component, and an oxide, said selected amount of said first carbonate component being between about 20.0% and about 35.0% by weight and said second carbonate component being provided in an amount of between about 10.0% and about 20.0% by weight.
    [17] 17. The dietary supplement of Claim 16, wherein said first carbonate component is calcium carbonate.
    [18] 18. The dietary supplement of Claim 16, wherein said second carbonate component is sodium sesquicarbonate.
    [19] 19. The dietary supplement of Claim 16, further including a selected amount of dimethyl glycine HCL.
    [20] 20. The dietary supplement of Claim 16, further including one or more vitamins selected from the group consisting of vitamins A, B, C, D and E.
    [21] 21. The dietary supplement of Claim 16, further including one or more amino acid chelates selected from the group consisting of selenium amino acid chelates, copper amino acid chelates, zinc amino acid chelates, manganese amino acid chelates, iodine amino acid chelates and chromium amino acid chelates.
    类似技术:
    公开号 | 公开日 | 专利标题
    US6143332A|2000-11-07|Nutritional supplement for the prevention and treatment of excessive intestinal permeability
    Ajibola et al.2012|Nutraceutical values of natural honey and its contribution to human health and wealth
    Goff2008|The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows
    Meyer et al.1987|Nutrition of the equine athlete
    GW III et al.2000|Activated charcoal attenuates bitterweed toxicosis in sheep.
    KR20170084317A|2017-07-19|Oral rehydration composition and methods thereof
    Van Saun2006|Nutritional diseases of South American camelids
    Saha et al.2016|Selenium in animal nutrition: Deficiencies in soils and forages, requirements, supplementation and toxicity
    Van Saun2009|Nutritional diseases of llamas and alpacas
    RU2494732C1|2013-10-10|Method for mineral metabolism correction in cows in biogeochemical province environment
    Pechova et al.2008|Monitoring of changes in selenium concentration in goat milk during short-term supplementation of various forms of selenium
    RU2739401C1|2020-12-23|Phytosynbiotic fodder additive for calves
    CA2361323C|2014-08-05|Nutritional supplement for the prevention and treatment of excessive intestinal permeability
    RU2348174C1|2009-03-10|Fodder additive for sucking period piglets
    RU2724510C1|2020-06-23|Phytomineral fodder additive for calves
    Williams1959|Biochemical individuality and cellular nutrition: Prime factors in alcoholism
    RU2268040C2|2006-01-20|Preparation for treating diarrhea in youngsters of farm animals and method for its application
    CA2224568A1|1997-01-03|Nutritional supplement
    RU2420089C2|2011-06-10|Dietary fodder supplement for broiler chickens
    RU2324361C1|2008-05-20|Natural biologically active fodder additive "vita-fortse"
    CN107647115A|2018-02-02|A kind of feed addictive of anti-heat stress and preparation method and application
    RU2695069C1|2019-07-19|Method for treating cattle in buxtonella disease
    RU2677475C1|2019-01-17|Method of treating calf gastroenteritis in conditions of technogenic provinces with excess lead, nickel and cadmium
    Babin et al.2016|Animal models for testing antidotes against an oral cyanide challenge
    DE10349585A1|2005-06-16|Trace element composition for the diet
    同族专利:
    公开号 | 公开日
    CA2361323C|2014-08-05|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20090169566A1|2004-11-22|2009-07-02|Anadis Ltd.|Bioactive compositions|
    WO2018144911A1|2017-02-02|2018-08-09|Golo Llc|Formulations for weight loss and methods of use|
    法律状态:
    2006-11-03| EEER| Examination request|
    优先权:
    申请号 | 申请日 | 专利标题
    US70818100A| true| 2000-11-07|2000-11-07||
    US09/708,181||2000-11-07||
    [返回顶部]